Efficacy of monotherapy with 15 antihypertensive agents in treating essential hypertension assessed by 24-hour ambulatory blood pressure monitoring / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 792-796, 2007.
Article
em Zh
| WPRIM
| ID: wpr-298686
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of the monotherapy of 15 agents in treating essential hypertension.</p><p><b>METHODS</b>After 2-week wash-out, a total of 370 patients with seated diastolic blood pressure 95-114 mmHg and seated systolic blood pressure < 180 mmHg were randomized to different therapeutic groups. 24-hour ambulatory blood pressure monitoring was performed before medication and at the end of 8 weeks.</p><p><b>RESULT</b>All the agents significantly reduced the 24 hour mean blood pressures after treatment except doxazosin, terazosin, and torasemide.</p><p><b>CONCLUSION</b>The result suggested that the angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers and long-acting calcium antagonists were effective in treating essential hypertension, while the low-dose doxazosin, terazosin and torasemide can be used for combination therapy but not for monotherapy.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Sulfonamidas
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Prazosina
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Inibidores da Enzima Conversora de Angiotensina
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Bloqueadores dos Canais de Cálcio
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Resultado do Tratamento
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Classificação
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Doxazossina
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Antagonistas Adrenérgicos beta
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Monitorização Ambulatorial da Pressão Arterial
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Usos Terapêuticos
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2007
Tipo de documento:
Article