Expression of melanoma antigen-1, 3 genes in human intrahepatic cholangiocarcinoma and its clinical significance / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 197-200, 2008.
Article
em Zh
| WPRIM
| ID: wpr-298713
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the possibility of using melanoma antigen (MAGE)-1 and MAGE-3 gene encoding proteins as an index of potential target for immunotherapy in intrahepatic cholangiocarcinoma (IHCC) patients.</p><p><b>METHODS</b>The expressions of MAGE-1 and MAGE-3 genes in tumor tissues and tumor adjacent non-IHCC liver tissues were examined by RT-PCR method. The relationship between positive expression rates of MAGE-1 and MAGE-3 genes and clinical data including sex, age, tumor diameters, tumor envelope, tumor nodules number, and hepatitis B virus surface antigen were determined.</p><p><b>RESULTS</b>The positive expression rates of MAGE-1 (35%) and MAGE-3 genes (45%) were significantly higher in the tumor tissues than in tumor adjacent tissues (0) (P<0.01). The positive expression rates of MAGE-1 and MAGE-3 genes had no relationship with the clinical data (P >0.05), except the morphology of tumor (P <0.05).</p><p><b>CONCLUSION</b>The high expression rates of MAGE-1 and MAGE-3 genes in IHCC suggests the MAGE-1 and MAGE-3 gene may be a target for immunotherapy in IHCC patients.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
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Neoplasias dos Ductos Biliares
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Ductos Biliares Intra-Hepáticos
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Técnicas In Vitro
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Colangiocarcinoma
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Reação em Cadeia da Polimerase Via Transcriptase Reversa
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Antígenos Específicos de Melanoma
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Genética
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Neoplasias Hepáticas
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Antígenos de Neoplasias
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2008
Tipo de documento:
Article