Efficacy and safety of gefitinib or docetaxel in Chinese patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who had failed previous platinum-based first-line chemotherapy / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 377-380, 2011.
Article
em Zh
| WPRIM
| ID: wpr-303292
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the efficacy and safety of gefitinib or docetaxel in Chinese patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who had failed previous platinum-based first-line chemotherapy.</p><p><b>METHODS</b>We retrospectively reviewed 222 Chinese NSCLC patients in the subgroup of INTEREST (gefitinib versus docetaxel in previously treated non-small cell lung cancer) study. Survival analysis was evaluated by Kaplan-Meier method, and Functional Assessment of Cancer Therapy-Lung (FACT-L) was used to compare the quality of life between gefitinib group and docetaxel group.</p><p><b>RESULTS</b>A total of 222 patients were analyzed in this subgroup study. 107 patients were treated with gefitinib, and 115 patients treated with docetaxel. There were all balanced between the two groups in terms of sex, age, staging and pathology in patient characteristics. The median overall survival in the two groups was similar (11 months in the gefitinib group vs. 14.0 months in the docetaxel group, P = 0.783). The progression-free survival (PFS) was also similar between the two groups (median PFS 3.4 months in gefitinib group vs. 3.8 months in docetaxel group, P = 0.214). The response rate in gefitinib group was significantly higher than that in the docetaxel group (21.9% vs. 9.1%, P = 0.016).</p><p><b>CONCLUSION</b>The efficacy of gefitinib is similar with that of docetaxel in pretreated patients with locally advanced or metastatic NSCLC, however, gefitinib is more favorable in the tolerance and quality of life improvement.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Platina
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Qualidade de Vida
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Quinazolinas
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Indução de Remissão
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Ensaios Clínicos Controlados Aleatórios como Assunto
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Taxa de Sobrevida
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Estudos Retrospectivos
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Carcinoma Pulmonar de Células não Pequenas
/
Intervalo Livre de Doença
Tipo de estudo:
Observational_studies
Aspecto:
Patient_preference
Limite:
Adult
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Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2011
Tipo de documento:
Article