Relationship of MTHFR gene polymorphisms with infertility / 中华男科学杂志
National Journal of Andrology
; (12): 171-174, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-304731
Biblioteca responsável:
WPRO
ABSTRACT
The folate metabolic pathway plays important roles in cellular physiology by participating in nucleotide synthesis, DNA repair and methylation, and maintenance and stability of the genome. Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme involved in folate metabolism. Polymorphisms of MTHFR may change the level of homocysteine and affect DNA synthesis and methylation, leading to an increased oxidative stress and disturbed methylation reactions and consequently affecting reproductive function. This article presents an overview on MTHFR gene polymorphisms, proposing that multicentered, large-sample and long-term prospective studies are needed to reveal the relationship between MTHFR gene polymorphisms and infertility.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
DNA
/
Estudos Prospectivos
/
Metilação de DNA
/
Metilenotetra-Hidrofolato Redutase (NADPH2)
/
Reparo do DNA
/
Ácido Fólico
/
Genética
/
Homocisteína
/
Infertilidade
Tipo de estudo:
Estudo observacional
Limite:
Humanos
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2016
Tipo de documento:
Artigo