Study on biomarker of Tripterygium wilfordii in treatment of rheumatoid arthritis based on PK/PD / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 334-338, 2015.
Article
em Zh
| WPRIM
| ID: wpr-305298
Biblioteca responsável:
WPRO
ABSTRACT
To observe the serum samples and the anti-inflammatory effect of Tripterygium wilfordii in treating RA by using the pharmacokinetic-pharmacodynamic model, make a correlation analysis on concentration-time and effect-time curves, and explore RORγt, IL-17, STAT3, IL-6 mRNA transcriptional levels in rats by PCR. Methotrexate, tripterine and high-dose T. wilfordii could down-regulate RORγt, IL-17, STAT3, IL-6 mRNA transcriptional levels in AA rat lymph nodes. The study on PK-PD model showed correlations between inflammatory factors and blood concentration of T. wilfordii. T. wilfordii and its main active constituent tripterine could show the inflammatory effect and treat RA by inhibiting IL-17 cytokine.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Artrite Reumatoide
/
Triterpenos
/
Farmacocinética
/
Biomarcadores
/
Interleucina-6
/
Ratos Sprague-Dawley
/
Interleucina-17
/
Tripterygium
/
Tratamento Farmacológico
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Article