Association between genetic polymorphism in STK15 and risk of colorectal cancer in a Chinese population / 中华肿瘤杂志

ABSTRACT

<p><b>OBJECTIVE</b>This case-control study was designed to detect the association between STK15 Phe31Ile polymorphism and colorectal cancer.</p><p><b>METHODS</b>Genotypes were determined in 283 patients with colorectal cancer and 283 controls. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression model.</p><p><b>RESULTS</b>The frequency of the STK15 Ile/Ile genotype was significantly higher in cancer cases than in controls (50.2% vs. 36.8%; P = 0.02). Subjects with the Ile/Ile genotype had an increased risk for the occurrence of colorectal cancer compared with those with the STK15 Phe/Phe genotype (adjusted OR, 1.92; 95% CI, 1.13 - 3.27). No significant association was observed between this STK15 polymorphism and risk of metastasis of the cancer.</p><p><b>CONCLUSION</b>These findings suggest that STK15 Phe/Ile polymorphism may be a genetic susceptibility factor for colorectal cancer among Chinese.</p>