The effect of portal hypertension on prognosis in patients with decompensated liver cirrhosis / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 263-265, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-310114
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of portal hypertension on prognosis in patients with decompensated liver cirrhosis.</p><p><b>METHODS</b>The clinical data of decompensated cirrhosis patients in our hospital, between 2003 and 2006, were retrospected and followed up. Model for end-stage liver disease (MELD) score and Child-Turcotte-Pugh (CTP) classification was calculated using the standard formula. Kaplan-Meier survival analysis was used to compare the mortality in subgroups ranked by the syndromes. Cox proportional hazards regression was used to evaluate the effect of the syndromes on prognosis.</p><p><b>RESULTS</b>A cohort of 322 patients was admitted in this study at the end of the follow-up. The mortality of variceal bleeding, hepatic encephalopathy, a large volume ascites, spontaneous bacterial peritonitis, the type I and type II hepatorenal syndrome was 45.9%, 79.4%, 66.7%, 100%, 100% and 84.6% respectively. On the whole, the occurrence of all the syndromes was correlated with CTP classification and MELD score. Kaplan-Meier survival analysis showed that all of these syndromes, except for low to medium volume of ascites, significantly affected the survival rate (P<0.01). In Cox regression analysis, all the syndromes were the independent predictors of prognosis, the regression coefficient values of hepatic encephalopathy, spontaneous bacterial peritonitis, type I and type II hepatorenal syndrome, variceal bleeding and ascites were 0.973, 0.928, 0.935, 0.866, 0.464 and 0.369 respectively.</p><p><b>CONCLUSIONS</b>The portal hypertensive syndromes have significant effect on the prognosis of the patients with decompensated cirrhosis, hepatic encephalopathy is the worst one.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
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ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
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ODS3 - Meta 3.2 Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
Problema de saúde:
Meta 3.2: Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
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Hipertensão Arterial
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Doença Cardiovascular
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Cirrose
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Doenças do Sistema Digestório
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Doenças do Sistema Endócrino
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Cuidados de Saúde Neonatal
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Doenças Não Transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
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Prognóstico
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Índice de Gravidade de Doença
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Síndrome Hepatorrenal
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Varizes Esofágicas e Gástricas
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Análise de Sobrevida
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Encefalopatia Hepática
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Epidemiologia
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Valor Preditivo dos Testes
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Seguimentos
Tipo de estudo:
Estudo observacional
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Estudo prognóstico
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Fatores de risco
Limite:
Adulto
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Idoso
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Feminino
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Humanos
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2009
Tipo de documento:
Artigo