DNA Methylation and Birth Weight: a Genome-wide Analysis / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 667-670, 2017.
Article
em En
| WPRIM
| ID: wpr-311364
Biblioteca responsável:
WPRO
ABSTRACT
The study illustrate the inner correlation between global DNA methylation variation and different birth weights. Infant birth weight was used to identify cases and controls. Cord blood and placentas were collected. We performed DNA methylation profiling of bisulphite-converted DNA. We have identified many differentially methylated CpG sites in experimental groups; these sites involved in hundreds of signalings. Among these, more than ten pathways were referred to the glucose and lipid metabolism. Methylation changes in the insulin-signaling pathway (ISP), adipocytokine signaling pathway (ASP) and MAPK signaling pathway are involved in the fetal programming of diabetes..
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Tamanho do Órgão
/
Fisiologia
/
Placenta
/
Peso ao Nascer
/
Transdução de Sinais
/
Regulação da Expressão Gênica no Desenvolvimento
/
Metilação de DNA
/
Estudo de Associação Genômica Ampla
Limite:
Female
/
Humans
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Male
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Newborn
/
Pregnancy
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2017
Tipo de documento:
Article