Comparative analysis of measles genome between vaccine strain and wild-type strain in Zhejiang province of China / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 723-726, 2009.
Article
em Zh
| WPRIM
| ID: wpr-316107
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the distinction between wild-type strain MVi/Zhejiang, CHN/7.05/4 and vaccine strain Shanghai-191 at genome level.</p><p><b>METHODS</b>After sequencing of measles wild-stain MVi/Zhejiang. CHN/7.05/4, the distinction between the wild-type strain and the vaccine strain was analysed by MEGA 3.1 software at genome level, and the antigen variation was studied by means of combining the epidemiological data.</p><p><b>RESULTS</b>There were 822 nucleotide differences (5.17%) and 161 amino acid differences between these two strains, including three glycosylation sites variation found. Meanwhile, the antigen ratio between wild-type strain and vaccine strain was found to be 5.66.</p><p><b>CONCLUSION</b>There should be certain differences between the contemporary wild-type strain MVi/Zhejiang, CHN/7.05/4 and vaccine strain Shanghai-191 at genome level, and the protective effects of measles vaccine should be studied further.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Virologia
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Variação Antigênica
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Vacina contra Sarampo
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China
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Epidemiologia
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Classificação
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Genoma Viral
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Análise de Sequência de RNA
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Análise de Sequência de Proteína
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Alergia e Imunologia
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Preventive Medicine
Ano de publicação:
2009
Tipo de documento:
Article