Prognostic significance of serum anti-Epstein-Barr virus antibodies in nasopharyngeal carcinoma / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 119-122, 2013.
Article
em Zh
| WPRIM
| ID: wpr-318087
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This study was aimed to investigate the association between serum against Epstein-Barr virus (EBV) antibodies levels and nasopharyngeal carcinoma (NPC) patients' prognosis.</p><p><b>METHODS</b>Blood samples from 140 primary NPC patients without metastasis were collected before and after treatment. The titers of VCA/IgA and EA/IgA were detected by immunoenzyme assay, and the levels of NA1/IgA and Rta/IgG were detected by enzyme-linked immunosorbent assay (ELISA). All patients received consequent follow-up and long-term efficacy and survival assessment.</p><p><b>RESULTS</b>Post-treatment serum levels of VCA/IgA, EA/IgA, NA1/IgA and Rta/IgG in NPC patients significantly decreased than those before treatment, while had significantly higher than those in control individuals (P < 0.05). Patients in remission had significantly lower pre-treatment serum levels of VCA/IgA and EA/IgA than patients with progression (P < 0.05). None of serum levels of VCA/IgA, EA/IgA, NA1/IgA and Rta/IgG was associated with the 3-year overall survival (P > 0.05). The progression-free survivals were significantly lower in patients with higher pre-treatment VCA/IgA (> or = 1 : 320) and EA/IgA (> or = 1:80) levels than in those with lower VCA/IgA ( < 1 : 320) and EA/IgA (< 1 : 80) levels, respectively (61.8% vs. 86.5% , 61.3% vs. 86.5%, P < 0.001). Cox regression model analysis demonstrated that pre-treatment serum VCA/IgA level was an independent risk factor for progression-free survival (HR = 3.80, P = 0.001).</p><p><b>CONCLUSION</b>Anti-EBV VCA/IgA and EA/IgA might provide information regarding the prognosis of NPC patients.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Prognóstico
/
Virologia
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Sangue
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Imunoglobulina A
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Carcinoma
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Neoplasias Nasofaríngeas
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Mortalidade
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Herpesvirus Humano 4
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Proteínas do Capsídeo
/
Alergia e Imunologia
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2013
Tipo de documento:
Article