Longitudinal Assessment of Cognitive Function in Patients with Juvenile Myoclonic Epilepsy / 대한간질학회지
Journal of Korean Epilepsy Society
; : 85-91, 2008.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-31837
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE:
We investigated the cognitive change of patients with juvenile myoclonic epilepsy (JME) after a long-term antiepileptic drug(s) (AED) administration to clarify the cause of cognitive impairment.METHODS:
Thirty-three patients with JME who were newly diagnosed or did not take any AED for at least 6 months prior to the beginning of the study were included. We conducted neuropsychological tests at baseline and after at least 12 months of AEDs trial. Forty healthy controls were acquired according to age- and education-match to patients with JME. We compared the differences of neuropsychological outcomes among them. We tried to identify the determinants for cognitive performances after AEDs trial.RESULTS:
Twenty-seven patients completed the second neuropsychological tests. Seizure frequency and EEG abnormality were significantly decreased after AEDs intake. The Number of epileptiform discharges (EDs) on EEG tended to be decreased at last visit. However, cognitive performances between baseline and follow-up period were not different. Cognitive measures of baseline and follow-up period were worse than those of controls in list learning, forward digit span, backward digit span, Trail Making Test, and verbal fluency. Cognitive performances of follow-up period in the JME group were not correlated with age at seizure onset, duration of epilepsy, seizure recurrence, EEG abnormality, and type of AEDs.CONCLUSIONS:
Cognitive performances of JME were not recovered to the level of healthy controls despite the control of seizures and EDs by AEDs. Therefore, cognitive impairment of JME may be due to irreversible, disease-related characteristics.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Convulsões
/
Teste de Sequência Alfanumérica
/
Seguimentos
/
Cognição
/
Epilepsia Mioclônica Juvenil
/
Eletroencefalografia
/
Epilepsia
/
Aprendizagem
/
Testes Neuropsicológicos
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Epilepsy Society
Ano de publicação:
2008
Tipo de documento:
Artigo