Synthesis and characterization of protocatechuic acid derivants / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 208-211, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-318691
Biblioteca responsável:
WPRO
ABSTRACT
To explore the effects of protocatechuic acid (PCA) and its derivants on angiogenesis of the chick embryo chorioallantoic membrane (CAM) and scavenging DPPH radical in vitro. The protection of benzyl and alkaline hydrolysis of benzyl ester were employed. The structures of PCA-1, PCA-2 and PCA-3, the derivates of PCA, were elucidated by 1H, 13C-NMR and MS data The bioactivity of PCA and its derivants was evaluated on the models of DPPH radical and chick embryo chorioallantoic membrane (CAM), respectively. PCA and PCA-1 showed the best activity of scavenging DPPH radical among all the compounds. In contrast to PCA-2, PCA and PCA-3 displayed inhibition to angiogenesis (P < 0.001). Pyrocatechol hydroxyl is the active site of PCA on scavenging DPPH radical in vitro. PCA with carboxyl and without pyrocatechol hydroxyl seems to show promotion to angiogenesis, but it needs more evidences.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Picratos
/
Compostos de Bifenilo
/
Medicamentos de Ervas Chinesas
/
Espectroscopia de Ressonância Magnética
/
Estrutura Molecular
/
Catecóis
/
Química
/
Sequestradores de Radicais Livres
/
Indutores da Angiogênese
/
Membrana Corioalantoide
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2013
Tipo de documento:
Artigo