Association between genetic polymorphisms in methylentetrahydrofolate reductase and risk of lung cancer / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 700-703, 2005.
Article
em Zh
| WPRIM
| ID: wpr-318833
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between methylentetrahydrofolate reductase (MTHFR) polymorphisms and risk of lung cancer.</p><p><b>METHODS</b>Totally 505 cases with lung cancer and 500 frequency-matched controls were genotyped for the MTHFR C677T and A1298C polymorphisms by polymerase chain reaction-restriction fragment length polymorphism methods. The odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression model. Haplotype frequency was estimated using EH software.</p><p><b>RESULTS</b>The frequency of the MTHFR C677T allele in cases was significantly higher than that in controls (53.5% vs 44.9%, P < 0.001). Compared with the 677CC genotype, the 677CT and 677TT genotypes were associated with increased risk of lung cancer, with the OR being 1.43 (95% CI, 1.04-1.95) and 2.40 (95% CI, 1.61-3.59), respectively. In addition, a significant difference in the distribution of haplotype frequencies between cases and controls was observed.</p><p><b>CONCLUSION</b>Functional polymorphism in MTHFR is associated with increased risk of lung cancer in Chinese population.</p>
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Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
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Estudos de Casos e Controles
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Risco
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Predisposição Genética para Doença
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Metilenotetra-Hidrofolato Redutase (NADPH2)
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Frequência do Gene
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Genética
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Genótipo
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Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2005
Tipo de documento:
Article