Clinicopathology and immunohistochemistry of adult type pulmonary blastoma / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the clinicopathologic and immunohistochemical features of adult type pulmonary blastoma (PB).</p><p><b>METHOD</b>Four cases of adult type PB were studied with light microscopy and immunohistochemical staining.</p><p><b>RESULTS</b>Three cases of PB were biphasic type and were composed of primitive epithelial component and primitive stromal component; one case of PB was epithelial type and was shown as branching glands with clustered and well-differentiated structure. Immunohistochemical studies showed that AE1/AE3 was positive in the epithelial component in four cases, Vimentin was positive in the stromal component in three cases, thyroid transricption factor-1 was positive in two cases, CD117 was positive in one case, Ki-67 was 2% positive in one case, while P53 was negative in all cases.</p><p><b>CONCLUSIONS</b>The adult type PB is a rarely seen biphasic tumor. It contains a primitive epithelial component and a primitive mesenchymal stroma, which looks like well-differentiated fetal adenocarcinoma. As highly invasive intrathoracic neoplasm, it is mainly found in adult with an unfavorable outcome.</p>