The study of the in vivo-in vitro correlation of the naftopidil sustained-release tablet in dog / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 826-843, 2006.
Article
em Zh
| WPRIM
| ID: wpr-320474
Biblioteca responsável:
WPRO
ABSTRACT
We studied the correlation of sustained-release tablet of naftopidil between the in vitro release and the in vivo absorption in the dog. The release rate (X) of naftopidil sustained-release tablet in artificial gastric fluid was determined and the naftopidil concentration in plasma was determined after a single oral dose of 100 mg naftopidil (tablet or sustained-release tablet) in the dog. The absorbed fraction(F) and in vivo absorption rate (A) of the NAF sustained-release tablet in the dog at different time were calculated by W-N method and deconvolution method, respectively. Then the regression equations between F or A and X of the corresponding time point were obtained F=2. 1533X - 27. 636(r = 0.9927) and A=2.3452X - 25.474(r= 0.9938). W-N method and deconvolution method both indicated that the correlation between the in vitro release and the in vivo absorption in the dog of the NAF sustained-release tablet was good.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Piperazinas
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Solubilidade
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Comprimidos
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Farmacocinética
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Disponibilidade Biológica
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Química
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Preparações de Ação Retardada
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Naftalenos
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2006
Tipo de documento:
Article