Protective effect of Shenxiong injection on cerebral ischemia-reperfusion injury of rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 503-506, 2014.
Article
em Zh
| WPRIM
| ID: wpr-321397
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the protective effect of Shenxiong injection on the cerebral ischemia-reperfusion injury of senile rats.</p><p><b>METHOD</b>Totally 108 Sprague-Dawley (SD) rats were randomly divided into the sham operation group, the model group, the Ni-modipine group and Shenxiong injection groups (low, middle, and high doses). The rat brain ischemia-reperfusion model was established by the middle cerebral artery occlusion (MCAO) method in rats, in order to observe the effect of Shenxiong injection on neurological score and brain infarct volume of rats with cerebral ischemia-reperfusion injury, and determine the contents of NOS, NO, SOD, MDA and LDH in brain tissues. The contents of TNF-alpha and IL-1beta levels in brain tissues were measured by enzyme-linked immunosorbent assay (ELISA) method.</p><p><b>RESULT</b>Shenxiong injection could significantly decrease neurological score, injury degree of brain tissues and brain infarct volume of rats with cerebral ischemia-reperfusion injury, increase the vigor of SOD, decrease the levels of MDA, NO, NOS and LDH, and inhibit IL-1beta and TNF-alpha expressions.</p><p><b>CONCLUSION</b>Shenxiong injection has the obvious protective effect on the brain ischemia-reperfusion injury in rats. Its mechanism may be related to the improvement of neurological function, the reduction of free radical injury, and the inhibition of inflammation factor expression.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Superóxido Dismutase
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Encéfalo
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Medicamentos de Ervas Chinesas
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Traumatismo por Reperfusão
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Isquemia Encefálica
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Ratos Sprague-Dawley
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Óxido Nítrico Sintase
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Usos Terapêuticos
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Tratamento Farmacológico
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2014
Tipo de documento:
Article
País de publicação:
CHINA
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CN
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REPUBLIC OF CHINA