Drug resistance of leukemic stem cells mediated by hedgehog signaling pathway / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 250-253, 2013.
Article
em Zh
| WPRIM
| ID: wpr-325174
Biblioteca responsável:
WPRO
ABSTRACT
Drug resistance and relapse are the major challenge for current treatment of acute leukemia. It is critical for ultimately curing leukemia to overcome chemoresistance of leukemic stem cells (LSC) and to eradicate LSC. Recent studies have found that abnormal activated Hedgehog (HH) signaling pathway plays an important role in a wide variety of tumors and regulates multi-drug resistance of LSC. This review briefly summarizes the molecular mechanism of HH signal pathway inducing drug resistance of LSC and leading to novel strategies for eradicating LSC.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Células-Tronco Neoplásicas
/
Transdução de Sinais
/
Leucemia
/
Resistencia a Medicamentos Antineoplásicos
/
Proteínas Hedgehog
/
Metabolismo
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2013
Tipo de documento:
Article