Effect of jiangu granule on quality of bone in model rats with osteoporosis induced by ovariectomy / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 431-434, 2004.
Article
em Zh
| WPRIM
| ID: wpr-326730
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Jiangu granule (JGG) on quality of bone in model rats with osteoporosis.</p><p><b>METHODS</b>Osteoporosis model was established by means of ovariectomy. Bone mineral density (BMD) was measured with dual energy X-ray densitometry. Osseous tissue structure of upper tibia was observed by ono-decalcified section and toluidine blue staining, and morphometry was carried out. Compressive strength limit and elastic modulus of first lumbar vertebrae, and bend load of femur were measured by light-based elastometer.</p><p><b>RESULTS</b>JGG can significantly increase BMD, area of trabecula and thickness of bone cortex/diameter of marrow cavity ratio of model rats, to elevate the compressive strength limit of vertebrae and bend load of femur.</p><p><b>CONCLUSION</b>JGG could increase BMD of osteoporosis model rats, and also could effectively improve the structure of osseous tissue, biomechanical property of bone and enhance the overall quality of bone.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Osteoporose
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Farmacologia
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Fenômenos Biomecânicos
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Medicamentos de Ervas Chinesas
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Ovariectomia
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Distribuição Aleatória
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Absorciometria de Fóton
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Densidade Óssea
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Ratos Sprague-Dawley
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Usos Terapêuticos
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Ano de publicação:
2004
Tipo de documento:
Article