Effect of jiangu granule on quality of bone in model rats with osteoporosis induced by ovariectomy / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect of Jiangu granule (JGG) on quality of bone in model rats with osteoporosis.</p><p><b>METHODS</b>Osteoporosis model was established by means of ovariectomy. Bone mineral density (BMD) was measured with dual energy X-ray densitometry. Osseous tissue structure of upper tibia was observed by ono-decalcified section and toluidine blue staining, and morphometry was carried out. Compressive strength limit and elastic modulus of first lumbar vertebrae, and bend load of femur were measured by light-based elastometer.</p><p><b>RESULTS</b>JGG can significantly increase BMD, area of trabecula and thickness of bone cortex/diameter of marrow cavity ratio of model rats, to elevate the compressive strength limit of vertebrae and bend load of femur.</p><p><b>CONCLUSION</b>JGG could increase BMD of osteoporosis model rats, and also could effectively improve the structure of osseous tissue, biomechanical property of bone and enhance the overall quality of bone.</p>