Cis-CA1P inhibits tumor cell proliferation and prevents blood vessel formation / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 15-18, 2012.
Article
em Zh
| WPRIM
| ID: wpr-329958
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of cis-combretastatin-A1 phosphate (cis-CA1P) on tumor cell proliferation, and its effects on the blood vessel formations.</p><p><b>METHODS</b>MTT and IC50 values were used to assess the inhibitory effects of cis-CA1P on tumor cell proliferation. Chicken embryo chorioallantoic membrane and thoracic aorta annulations isolated from rats were used to investigate the effects of cis-CAIP on the blood vessel formation.</p><p><b>RESULTS</b>Cis-CA1P concentration-dependently inhibited the proliferations of several cancer cell lines, including human gastric carcinoma cell line MGC-803, human leukemic monocyte lymphoma cell line U937, human melanoma cell line A375, human colon cancer cell line HCT116, human breast carcinoma cell line MDA-MB-231, and human leukemia cell line K562. Cis-CAIP significantly decreased the formation of blood vessels in chicken embryo chorioallantoic membrane and in thoracic aorta annulations.</p><p><b>CONCLUSION</b>Cis-CA1P inhibits cancer cell proliferation and prevents blood vessel formation.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Aorta
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Farmacologia
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Fosfatos
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Estilbenos
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Técnicas In Vitro
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Química
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Linhagem Celular Tumoral
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Membrana Corioalantoide
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Proliferação de Células
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Neovascularização Patológica
Limite:
Animals
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Humans
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2012
Tipo de documento:
Article