Expression and significance of angiopoietins in oral squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 63-68, 2005.
Article
em Zh
| WPRIM
| ID: wpr-329984
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the expression of angiopoietins in oral squamous cell carcinoma and relationship between the expression of angiopoietins and pathologic classification.</p><p><b>METHODS</b>The expression of Ang-1 and Ang-2 protein in samples from 42 oral squamous cell carcinoma and 16 oral normal mucosa were detected by immunohistochemical technique.</p><p><b>RESULTS</b>The expression of Ang-1 and Ang-2 was found in both oral squamous cell carcinoma and normal control. It was found Ang-1 expression alike in oral squamous cell carcinoma and control (P > 0.05). Ang-2 expressed at low level in control while strongly positive in oral squamous cell caroinoma and the level of Ang-2 expression in oral squamous cell caroinoma was related to pathologic classification (P < 0.05).</p><p><b>CONCLUSION</b>Ang-2 expression in oral squamous cell carcinoma is related to angiogenesis and pathological classification, which is probably involved in angiogenesis regulation, promotes the development and metastasis of oral squamous cell carcinoma.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Angiopoietinas
/
Angiopoietina-1
/
Angiopoietina-2
/
Mucosa Bucal
/
Neoplasias
/
Neovascularização Patológica
Limite:
Humans
/
Male
Idioma:
Zh
Revista:
West China Journal of Stomatology
Ano de publicação:
2005
Tipo de documento:
Article