The effects of growth hormone on rabbit's mandibular condylar chondrocytes proliferation and secretion in vitro / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 370-372, 2004.
Article
em Zh
| WPRIM
| ID: wpr-330045
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of growth hormone (GH) on the proliferation and type II collagen secretion of chondrocytes of mandibular condyle in rabbit in vitro.</p><p><b>METHODS</b>Flow cytometry (FCM) and immunohistochemical technique were employed to observe the possible changes.</p><p><b>RESULTS</b>(1) The exogenic GH can enhance the proliferation and synthesis of DNA of the chondrocytes of mandibular condyle in rabbit in vitro. The suitable concentration of GH is 10 microg/ml. The synthesis of DNA reaches the highest level after 12 hours, while the proliferation index (PI) hits the highest after 24 hours. (2) GH (10 microg/ml) can stimulate the secretion of type II collagen of the chondrocytes.</p><p><b>CONCLUSION</b>The exogenic GH can enhance the proliferation, the synthesis of DNA and the secretion of type II collagen of the chondrocytes of mandibular condyle in rabbit in vitro.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Hormônio do Crescimento
/
Cartilagem Articular
/
Células Cultivadas
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Condrócitos
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Secreções Corporais
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Biologia Celular
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Colágeno Tipo II
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Proliferação de Células
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Côndilo Mandibular
Limite:
Animals
Idioma:
Zh
Revista:
West China Journal of Stomatology
Ano de publicação:
2004
Tipo de documento:
Article