Compatibility research of Yiqi Fumai injection with clinical combination based on isothermal titration calorimetry / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 889-893, 2015.
Article
em Zh
| WPRIM
| ID: wpr-330215
Biblioteca responsável:
WPRO
ABSTRACT
To reveal the characterization of interaction between Chinese and western medicinal injections, isothermal titration calorimetry (ITC) was applied to evaluating the interaction of Yiqi Fumai injection (YQFM, as mode drug) with epinephrine hydrochloride injection (YS) and 5% glucose injection (5% GS). The diversification of Gibbs free energy (ΔG), enthalpy (ΔH), and entropy (ΔS) were determined to judge the reaction types of colliquefaction procedures of different injections. Meanwhile, the fingerprints of YQFM before and after combined with the various injections were compared to validate the results. This work demonstrated that during the titration procedure of YQFM and YS, [ΔH] > T [ΔS] , that was to say the reaction was enthalpy-driving. And the reactive profile indicated that a great deal of heat gave out during the procedure. Obviously, chemical reactions happened and the internal component changed. On the other side, the reaction of YQFM combined with 5% GS was entropy-driving, because [ΔH] < T [ΔS]. The reactive profile showed there was only a little heat released. So non-chemical reactions happened and the major ingredients did not change. ITC could be applied to the evaluation on compatibility of other kinds of Chinese and western medicinal injection combination.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Termodinâmica
/
Calorimetria
/
Medicamentos de Ervas Chinesas
/
Epinefrina
/
Química
/
Entropia
/
Interações Medicamentosas
/
Glucose
/
Injeções
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Article