The action of decorin in anti-fibrosis and anti-cancer / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 222-225, 2007.
Article
em Zh
| WPRIM
| ID: wpr-331360
Biblioteca responsável:
WPRO
ABSTRACT
Decorin (DCN) is a member of the small leucine-rich proteoglycan gene family. Many studies indicated that DCN inhibited fibrosis and scar-formation by neutralization of TGF-P and interfering the binding of TGF-beta with its receptor, which induced ectopic deposition of extracellular matrix. Additionally, DCN can prevent the proliferation and metastasis of tumor cells by activating EGFR/MAPK/p21 signal pathway and inhibiting the cell proliferation pathway mediated by EGF-EGFR. It is suggested that the recombinant DCN had potential pharmaceutical potency in treatment of chronic fibrosis and neoplasm for its critical biological activities and low immunogenicity.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Proteoglicanas
/
Fibrose
/
Proteínas Recombinantes
/
Química
/
Proteínas da Matriz Extracelular
/
Fator de Crescimento Transformador beta1
/
Decorina
/
Receptores ErbB
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2007
Tipo de documento:
Article