Preliminary study on genotype of hepatitis B virus detected from Tibetans in China / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To determine the main genotype of hepatitis B virus (HBV) detected from Tibetans in China and provide basic data for hepatitis control and prevention.</p><p><b>METHODS</b>The S gene and C gene were amplified by PCR from the sera of HBsAg positive Tibetans. After sequencing, the gene sequences were analyzed and the phylogenetic trees were drawn by the software MEGA3.</p><p><b>RESULTS</b>In trees based on S gene, the sequences of most samples clustered at genotype D, while in trees based on C gene, the sequences of all samples clustered at genotype C.</p><p><b>CONCLUSION</b>The dominant genotype of HBV detected from Tibetans in China is a C/D hybrid.</p>