The experimental study of lipo-sodium morrhuate promoting apoptosis of ECV-304 cells / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the effect of lipo-sodium morrhuate on ECV-304 cell line.</p><p><b>METHODS</b>The effect lipo-sodium morrhuate was evaluated by toxicology trial (MTT), electron microscope, DNA electrophoresis and flow cytometer.</p><p><b>RESULTS</b>The toxicology results showed, that the number of vital cells in lipo-sodium morrhuate group decreased slowly. The electron microscope exhibited apoptosis in the lipo-sodium morrhuate group. And there were typical DNA ladder in DNA electrophoresis and typical apoptosis peak in flow cytometer. The apoptosis rate was 22.23%.</p><p><b>CONCLUSIONS</b>Unlike the normal preparation of sodium morrhuate, lipo-sodium morrhuate could induce apoptosis of ECV-304 cell line.</p>