Effect of bradykinin on the sodium channel current in dorsal root ganglion neuron / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 337-340, 2003.
Article
em Zh
| WPRIM
| ID: wpr-333758
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the effects of bradykinin on voltage-dependent sodium channel currents in rat dorsal root ganglion neurons (DRG).</p><p><b>METHODS</b>Whole-cell patch clamp technique was used to determine sodium channel current.</p><p><b>RESULTS</b>Bradykinin at 0.01 - 10.0 micromol/L dose dependently increased the frequency of repetitive firing of DRG. Bradykinin at 0.01 - 10.0 micromol/L dose dependently enhanced the TTX-R sodium current, and had no effect on TTX-S sodium current.</p><p><b>CONCLUSION</b>Mechanism underlying the inflammation induced by bradykinin is related to the TTX-R sodium channel.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Fisiologia
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Potenciais de Ação
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Bradicinina
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Canais de Sódio
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Ratos Sprague-Dawley
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Técnicas de Patch-Clamp
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Gânglios Espinais
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Potenciais da Membrana
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Neurônios
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2003
Tipo de documento:
Article