Molecular interaction between PrP protein and the signal protein 14-3-3 beta / 病毒学报
Chinese Journal of Virology
; (6): 208-212, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-334749
Biblioteca responsável:
WPRO
ABSTRACT
The molecular interaction between PrP and 14-3-3 beta and the possible interactional domain between two proteins were studied by co-immunoprecipitation, pull down and FRET assays. The results showed that PrP protein could interact with 14-3-3 beta in vitro and in vivo. The domain which responded for the interaction was located at C-terminal of PrP (amino acid residues 106 to 126). This study of the interaction between PrP and 14-3-3 protein further provided the insight into the potential role of 14-3-3 in the biological function of PrP and the pathogenesis of prion disease.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ligação Proteica
/
Encéfalo
/
Príons
/
Células HeLa
/
Transferência Ressonante de Energia de Fluorescência
/
Proteínas 14-3-3
/
Imunoprecipitação
/
Metabolismo
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Virology
Ano de publicação:
2009
Tipo de documento:
Artigo
