Analgesic effect of interleukin-2 in mouse models of spared nerve injury / 南方医科大学学报
Journal of Southern Medical University
; (12): 1180-1182, 2007.
Article
em Zh
| WPRIM
| ID: wpr-337301
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the analgesic effect of interleukin-2 (IL-2) in mice with spared nerve injury (SNI).</p><p><b>METHOD</b>IL-2 was intraperitoneally injected in mice with induced SNI, and von Frey Filaments test and cold plate test were carried out to accesses the analgesic effects of IL-2 and the effect of naloxone in antagonizing the effects of IL-2.</p><p><b>RESULTS</b>IL-2 produced analgesic effects against hyperalgesia and allodynia in mouse models of SNI, and the effect of IL-2 lasted for more than 24 h, showing a double-peak pattern in its action with the two peaks occurring at 30 and 105 min, respectively. The effect of IL-2 could be significantly antagonized by naloxone.</p><p><b>CONCLUSIONS</b>IL-2 has long-lasting analgesic effects in mouse models of SNI model, showing a double-peak pattern of its action. The analgesic effect of IL-2 is probably mediated by opiate receptor.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Interleucina-2
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Traumatismos do Sistema Nervoso
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Usos Terapêuticos
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Modelos Animais de Doenças
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Relação Dose-Resposta a Droga
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Tratamento Farmacológico
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Hiperalgesia
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Analgésicos
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Camundongos Endogâmicos BALB C
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2007
Tipo de documento:
Article