Study of screening pseudoallergenic substances of Shuanghuanglian injection / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2727-2731, 2015.
Article
em Zh
| WPRIM
| ID: wpr-337900
Biblioteca responsável:
WPRO
ABSTRACT
In this study, chemistry, biology and pharmacology were combinated to screen pseudoallergenic substances of Shuang-huanglian injection (SHLI) so that to establish a scientific and systematic approach to screen pseudoallergenic substances of traditional Chinese medicine injections. The mouse pseudoallergic reaction models were used to screen the pseudoallergic reaction of SHLI's intermediate extract and the intermediate extract's component or ingredient. Among the three intermediates of Shuanghuanglian injection (extract of Scutellaria baicalensis, extract of Lonicera japonica, extract of Forsythia suspensa) , pseudoallergic action of Forsythia suspensa was the strongest, Forsythia suspesnsa's pseudoallergic reaction mainly associated with the composition with largerchemical polarity. Further it was found that forsythiaside A and arctiin which existed in the the composition with largerchemical polarity caused obvious pseudoallergic reactions. SHLI with removal forsythoside A with the technology of HPLC-MS displayed reduced pseudoallergic reaction and a significant improved safety. This study provided a scientific basis for SHLI process improvements and also offered idea and research foundation for screening pseudoallergenic substances injections in other TCM injections.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Medicamentos de Ervas Chinesas
/
Hipersensibilidade a Drogas
/
Furanos
/
Glucosídeos
/
Glicosídeos
/
Injeções
/
Camundongos Endogâmicos ICR
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Article