Secondary metabolites from a deep-sea-derived actinomycete Micrococcus sp. R21 / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2367-2371, 2015.
Article
em Zh
| WPRIM
| ID: wpr-337927
Biblioteca responsável:
WPRO
ABSTRACT
To investigate cytotoxic secondary metabolites of Micrococcus sp. R21, an actinomycete isolated from a deep-sea sediment (-6 310 m; 142 degrees 19. 9' E, 10 degrees 54. 6' N) of the Western Pacific Ocean, column chromatography was introduced over silica gel, ODS, and Sephadex LH-20. As a result, eight compounds were obtained. By mainly detailed analysis of the NMR data, their structures were elucidated as cyclo(4-hydroxy-L-Pro-L-leu) (1), cyclo(L-Pro-L-Gly) (2), cyclo( L-Pro-L-Ala) (3), cyclo( D-Pro-L-Leu) (4), N-β-acetyltryptamine (5), 2-hydroxybenzoic acid (6), and phenylacetic acid (7). Compound 1 exhibited weak cytotoxic activity against RAW264. 7 cells with IC50 value of 9.1 μmol x L(-1).
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Filogenia
/
Água do Mar
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Espectrometria de Massas
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Espectroscopia de Ressonância Magnética
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Estrutura Molecular
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Fatores Biológicos
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Sobrevivência Celular
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Química
/
Biologia Celular
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Article