Effect of intra-testicular testosterone withdrawal on the expression of alpha-catenin in the adult rat testis / 中华男科学杂志
National Journal of Andrology
; (12): 394-400, 2006.
Article
em Zh
| WPRIM
| ID: wpr-338286
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of alpha-catenin in the rat testis after intra-testicular testosterone withdrawal induced by injection of testosterone undecanoate (TU).</p><p><b>METHODS</b>Ten adult male SD rats received vehicle (n = 5 ) or TU (19 mg/kg every 15 days, n = 5) for 130 days. Paraffin-embedded testicular sections were used for immunohistochemistry against a polyclonal anti-alpha-catenin antibody.</p><p><b>RESULTS</b>In the control, alpha-catenin was expressed in the acrosome of spermatids and the cytoplasm of Leydig cells and peritubular myoid cells. In the TU-treated rat testis, Leydig cells were atrophied and the expression of alpha-catenin was markedly decreased or absent, but there was no evident change in the immunostaining of spermatids or myoid cells.</p><p><b>CONCLUSION</b>Intra-testicular testosterone withdrawal-induced looser arrangement or sloughing of spermatogenic cells is not related to the adhesion molecule alpha-catenin. Alpha-catenin may be used as a cell identification marker for Leydig cells.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Testículo
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Testosterona
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Imuno-Histoquímica
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Ratos Sprague-Dawley
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Alfa Catenina
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Células Intersticiais do Testículo
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Metabolismo
Limite:
Animals
Idioma:
Zh
Revista:
National Journal of Andrology
Ano de publicação:
2006
Tipo de documento:
Article