Changes of serum angiogenesis in patients with chronic mountain sickness / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 457-460, 2009.
Article
em Zh
| WPRIM
| ID: wpr-340135
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>The clinical manifestation of chronic mountain sickness (CMS) is polycythemia, pulmonary hypertension and mionectic blood. However, the pathogenesis of it is not identified now. So it is necessary to investigate the effects of the angiogenic growth factors on the pathophysiologic development of CMS.</p><p><b>METHODS</b>The serum levels of basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) in 13 healthy Tibetan natives (Native), 17 healthy people in Xining (control group) and 35 CMS patients were determined by quantitative sandwich enzyme immunoassay. Meanwhile, the levels of Hb, Hct and SaO2 were determined.</p><p><b>RESULTS</b>The serum levels of bFGF (107.26 +/- 7.86) ng/L, PDGF (630.18 +/- 9.89) ng/L and VEGF (543.74 +/- 6.76) ng/L in CMS were significantly higher than those in Natives (37.01 +/- 9.16; 292.16 +/- 6.88; 125.51 +/- 7.26) ng/L, and in control group (40.58 +/- 5.34; 287.68 +/- 8.33; 76.26 +/- 4.60) ng/L, respectively (P < 0.01). There was no difference between the natives and the control group in bFGF and PDGF (P > 0.05), while there was predominant difference between the Natives and the control group in VEGF (P < 0.01). There was a predominant positive correlation between the serum levels of bFGF, PDGF or VEGF and hemoglobin concentrations in CMS respectively (P < 0.01). And there were positive relations between angiogenic growth factors each other.</p><p><b>CONCLUSION</b>The serum levels of bFGF, PDGF and VEGF in patients with CMS significantly increase, these angiogenic growth factors may play important role on the pathophysiologic development of CMS; the VEGF level likely contributes to the adaptation to plateau hypoxia in healthy Tibetan natives; the elevated bFGF, PDGF and VEGF levels are likely associated with excessive erythropoiesis in CMS.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Sangue
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Fator de Crescimento Derivado de Plaquetas
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Estudos de Casos e Controles
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Doença Crônica
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Fator 2 de Crescimento de Fibroblastos
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Fator A de Crescimento do Endotélio Vascular
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Doença da Altitude
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Metabolismo
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2009
Tipo de documento:
Article