Gene Expression Profile in Patients with Axial Spondyloarthritis: Meta-analysis of Publicly Accessible Microarray Datasets
Journal of Rheumatic Diseases
; : 363-372, 2016.
Article
em En
| WPRIM
| ID: wpr-34290
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To identify a gene expression signature in axial spondyloarthritis/ankylosing spondylitis (SpA/AS) and genomic pathways likely to be involved in pathogenesis of SpA/AS patients. METHODS: Four publicly accessible microarray studies from SpA/AS patients were integrated, and a transcriptomic and network-based meta-analysis was performed. This meta-analysis was compared with a published microarray study in whole blood of AS patients. RESULTS: According to our meta-analysis, 1,798 genes were differentially expressed in the whole blood of SpA/AS patients compared to healthy controls, while 674 genes were differentially expressed in the synovium of SpA/AS patients compared to healthy controls. When the whole blood meta-analysis data was compared with a published microarray study that also analyzed whole blood in SpA/AS patients, pathways involved in Toll-like receptor signaling, osteoclast differentiation, T cell receptor signaling and janus kinase–signal transducer and activator of transcription (Jak-STAT) signaling were often enriched in SpA/AS. On the other hand, eomesodermin, RUNX3, and interleukin-7 receptor (IL7R) were usually decreased in SpA/AS patients, suggesting that deficiency of these genes contributes to increased IL-17 production in AS. CONCLUSION: Several common enrichment pathways including Toll-like receptor signaling pathway, osteoclast differentiation, T cell receptor signaling pathway and Jak-STAT signaling pathway were identified in the differentially expressed genes of whole blood and synovium from SpA/AS patients, suggesting that these pathways are involved in the pathogenesis of SpA/AS.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Osteoclastos
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Espondilite
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Espondilite Anquilosante
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Membrana Sinovial
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Transdutores
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Receptores de Antígenos de Linfócitos T
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Expressão Gênica
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Genes vif
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Interleucina-7
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Interleucina-17
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Journal of Rheumatic Diseases
Ano de publicação:
2016
Tipo de documento:
Article