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Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: a double-blind randomized controlled trial / 华中科技大学学报(医学)(英德文版)
Article em En | WPRIM | ID: wpr-343120
Biblioteca responsável: WPRO
ABSTRACT
No direct comparison of tauroursodeoxycholic acid (TUDCA) and ursodeoxycholic acid (UDCA) has yet been carried out in the treatment of liver cirrhosis in China. We designed a double-blind randomized trial to evaluate the potential therapeutic efficacy of TUDCA in liver cirrhosis, using UDCA as parallel control. The enrolled 23 patients with liver cirrhosis were randomly divided into TUDCA group (n=12) and UDCA group (n=11), and given TUDCA and UDCA respectively at the daily dose of 750 mg, in a randomly assigned sequence for a 6-month period. Clinical, biochemical and histological features, and liver ultrasonographic findings were evaluated before and after the study. According to the inclusion criteria, 18 patients were included in the final analysis, including 9 cases in both two groups. Serum ALT, AST and ALP levels in TUDCA group and AST levels in UDCA group were significantly reduced as compared with baseline (P<0.05). Serum albumin levels were significantly increased in both TUDCA and UDCA groups (P<0.05). Serum markers for liver fibrosis were slightly decreased with the difference being not significant in either group. Only one patient in TUDCA group had significantly histological relief. Both treatments were well tolerated and no patient complained of side effects. It is suggested that TUDCA therapy is safe and appears to be more effective than UDCA in the treatment of liver cirrhosis, particularly in the improvement of the biochemical expression. However, both drugs exert no effect on the serum markers for liver fibrosis during 6-month treatment.
Assuntos
Texto completo: 1 Base de dados: WPRIM Assunto principal: Ácido Tauroquenodesoxicólico / Ácido Ursodesoxicólico / Colagogos e Coleréticos / Método Duplo-Cego / Resultado do Tratamento / Usos Terapêuticos / Diagnóstico / Tratamento Farmacológico / Cirrose Hepática Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J. huazhong univ. sci. tech. med. sci Ano de publicação: 2013 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Ácido Tauroquenodesoxicólico / Ácido Ursodesoxicólico / Colagogos e Coleréticos / Método Duplo-Cego / Resultado do Tratamento / Usos Terapêuticos / Diagnóstico / Tratamento Farmacológico / Cirrose Hepática Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: J. huazhong univ. sci. tech. med. sci Ano de publicação: 2013 Tipo de documento: Article