Effect of curcumin on JAK-STAT signaling pathway in hepatoma cell lines / 药学学报
Acta Pharmaceutica Sinica
; (12): 1434-1439, 2009.
Article
em Zh
| WPRIM
| ID: wpr-344058
Biblioteca responsável:
WPRO
ABSTRACT
The effect of curcumin on JAK-STAT signaling pathway was investigated in hepatoma cell lines Huh7 and Hep3B. Curcumin inhibited cell proliferation and induced apoptosis of both cell lines, but Huh7 cells were more sensitive to curcumin than Hep3B cells. Curcumin (50 micromol x L(-1)) significantly increased phosphorylations of p38 (T180/Y182) and STAT-1 (S727) in Huh7 and Hep3B cells, and caused relocalization of phosphorylated-STAT-1 (Y701) from cytoplasm to nucleus in Hep3B cells. In addition, curcumin (25 and 50 micromol x L(-1)) dramatically suppressed the phosphorylation level of STAT-1 (Y701) and resulted in a significant reduction of nuclear phosphorylated-STAT-1 (Y701) in Huh7 cells.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Farmacologia
/
Fosforilação
/
Plantas Medicinais
/
Transdução de Sinais
/
Química
/
Apoptose
/
Carcinoma Hepatocelular
/
Curcumina
/
Curcuma
Limite:
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Article