Effect of preoperative transcatheter arterial chemo-embolization on activity of cell proliferation in Wilms; tumor / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 83-87, 2008.
Article
em Zh
| WPRIM
| ID: wpr-344372
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of preoperative transcatherter arterial chemo-embolization (TACE) on the cell proliferation in Wilms; tumor.</p><p><b>METHODS</b>Forty-one cases of Wilms; tumor diagnosed by histopathology were divided into two groups: in TACE group, 23 patients received TACE first and were operated 2 weeks later; in control group, 18 patients were operated alone. A comparative analysis of the pathological finding was made in two groups, and the expression of PCNA and VEGF in tumor tissue was detected by immunohistochemistry.</p><p><b>RESULT</b>The degeneration of tumor tissue such as tumor cell necrotic, broken, disappearance occurred in 17 cases of TACE group and in 4 cases of control group, respectively (P <0.01). The expression of PCNA in TACE group and in control group was 1/23 (4.3 %) and 9/18(50.0 %), respectively (P <0.01). VEGF was expressed in 7/23 (30.4 %) of TACE group and 9/18 (50.0 %) of control group (P=0.283).</p><p><b>CONCLUSION</b>TACE can significantly inhibit proliferation and enhance degeneration of Wilms; tumor cells.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
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Cirurgia Geral
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Terapêutica
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Cuidados Pré-Operatórios
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Quimioembolização Terapêutica
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Tumor de Wilms
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Antígeno Nuclear de Célula em Proliferação
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Fator A de Crescimento do Endotélio Vascular
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Proliferação de Células
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Neoplasias Renais
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2008
Tipo de documento:
Article