Analysis of chemical constituents of chuanxiong rhizoma absorbed into rat brain tissues by UPLC-Q-TOF-MS / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3647-3650, 2012.
Article
em Zh
| WPRIM
| ID: wpr-346890
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze and identify the chemical constituents in rat brain tissues after oral administration of Chuanxiong Rhizoma extracts.</p><p><b>METHOD</b>The dosed and blank rat brain tissues were analyzed by UPLC-Q-TOF-MS. Different peaks were observed in total ion chromatograms and then identified according to their retention time, accurate mass weight, MS and MS/MS data.</p><p><b>RESULT</b>After oral administration of Chuanxiong Rhizoma extracts, 3 compounds were absorbed into rat brain tissues through BBB. They were identified as senkyunolide I, senkyunolide A and ligustilide.</p><p><b>CONCLUSION</b>The study is helpful for interpreting effective substance of Ligusticum chuanxiong.</p>
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Base de dados:
WPRIM
Assunto principal:
Espectrometria de Massas
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Encéfalo
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Medicamentos de Ervas Chinesas
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Farmacocinética
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Química
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Cromatografia Líquida de Alta Pressão
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Ratos Sprague-Dawley
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Ligusticum
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Rizoma
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Metabolismo
Limite:
Animals
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Female
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Humans
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2012
Tipo de documento:
Article