Changes in expression of gelatinase in young rat condylar cartilage during functional mandibular advancement / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 299-305, 2007.
Article
em Zh
| WPRIM
| ID: wpr-348097
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes in expression of gelatinase (MMP-2, MMP-9) in young rat condylar cartilage during functional mandibular advancement.</p><p><b>METHODS</b>Sixty male 5-week old SD rats were divided into experimental and control groups. The mimic functional appliances were used in experimental group rats. The animals were sacrificed after 1, 2, 4 weeks. The immunoreactivity of gelatinase was detected by immunohistochemistry.</p><p><b>RESULTS</b>In normal mandibular condylar cartilage, the immunoreactivity of MMP-2 was rather strong, the immunoreactivity of MMP-9 was very weak. Following functional mandibular advancement, the expression of MMP-9 was significantly increased (P < 0.01), but immunoreactivity of MMP-2 had no significant changes.</p><p><b>CONCLUSION</b>Gelatinase plays an important role in the adaptive remondling of young rat condylar cartilage during functional mandibular advancement.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Cartilagem
/
Ratos Sprague-Dawley
/
Gelatinases
/
Avanço Mandibular
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Metaloproteinase 2 da Matriz
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Côndilo Mandibular
Limite:
Animals
Idioma:
Zh
Revista:
West China Journal of Stomatology
Ano de publicação:
2007
Tipo de documento:
Article