Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy
Annals of Surgical Treatment and Research
; : 179-182, 2016.
Article
em En
| WPRIM
| ID: wpr-34974
Biblioteca responsável:
WPRO
ABSTRACT
5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Trombocitopenia
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Encefalopatias Metabólicas
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Sistema Nervoso Central
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Leucovorina
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Quimioterapia Adjuvante
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Neoplasias do Colo
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Hiperamonemia
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Tratamento Farmacológico
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Fluoruracila
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Amônia
Limite:
Humans
Idioma:
En
Revista:
Annals of Surgical Treatment and Research
Ano de publicação:
2016
Tipo de documento:
Article