Association of miR-199a expression with clinicopathologic characteristics and prognosis of renal cell carcinoma / 南方医科大学学报
Journal of Southern Medical University
; (12): 1568-1571, 2012.
Article
em Zh
| WPRIM
| ID: wpr-352384
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of miR-199a expression with the clinicopathologic characteristics and the survival of patients with renal cell carcinoma (RCC).</p><p><b>METHODS</b>Real-time quantitative RT-PCR was used to detect the expression of miR-199a in the tumor tissues and paired adjacent normal tissues from 67 patients with RCC. The correlations of miR-199a expression with the clinicopathologic characteristics and survival of RCC patients were analyzed.</p><p><b>RESULTS</b>Positive miR-199a expression was detected in both the RCC and adjacent normal tissues, but the tumor tissues showed a significantly lower expression level by a mean of 13.7 folds (P=0.003). The expression of miR-199a was negatively correlated with tumor recurrence in RCC patients in T stage (P<0.05), but showed no significant correlations with the patients age, histological type of the tumor, lymph node metastasis, distal metastasis, or Fuhrman grade (P>0.05). The patients with lowered miR-199a expression in the tumor tissue had a significantly shorter mean survival time than those without miR-199a down-regulation (P=0.017 by Log-rank test).</p><p><b>CONCLUSION</b>A decreased expression of miR-199a is significantly correlated with a higher tumor stage, a greater likeliness of tumor recurrence, and a poorer prognosis in RCC patients. miR-199a can serve as a promising prognostic factor of renal cell carcinoma.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
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Prognóstico
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Carcinoma de Células Renais
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Regulação para Baixo
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MicroRNAs
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Neoplasias Renais
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Metabolismo
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Metástase Neoplásica
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2012
Tipo de documento:
Article