Design, synthesis and in vitro activity of glycinamide-bearing compounds as DPP-IV inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 1379-1384, 2010.
Article
em Zh
| WPRIM
| ID: wpr-353350
Biblioteca responsável:
WPRO
ABSTRACT
To research the structure-activity relationship (SAR) of glycinamide-bearing compounds that used as inhibitors of dipeptidyl peptidase IV (DPP-IV), P32/98 and compound A were chosen as the leading compounds, heterocycles containing nitrogen atom were introduced to form amide, and different residues on a-position of carbonyl were designed. The nineteen designed compounds were synthesized by a simple route and were evaluated as inhibitors of DPP-IV. All of the structures were characterized by 1H NMR and HRMS. The preliminary SAR result was obtained.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Piperazinas
/
Relação Estrutura-Atividade
/
Espectroscopia de Ressonância Magnética
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Desenho de Fármacos
/
Estrutura Molecular
/
Química
/
Dipeptidil Peptidase 4
/
Inibidores da Dipeptidil Peptidase IV
/
Glicina
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2010
Tipo de documento:
Article