Modulation effect of bis (alpha-furancarboxylato) oxovanadium (IV) on blood glucose in diabetic rats / 药学学报
Acta Pharmaceutica Sinica
; (12): 496-500, 2005.
Article
em Zh
| WPRIM
| ID: wpr-353486
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To study the hypoglycemic effect of bis (alpha-furancarboxylato) oxovanadium (IV) (VO-FA) in normal rats and streptozotocin (STZ)-diabetic rats.</p><p><b>METHODS</b>Rats were injected intraperitoneally STZ 50 mg.kg(-1) to induce diabetes. Blood glucose, glycohemoglobin, glycogen and serum insulin were observed after administering intragastrically VO-FA for four weeks.</p><p><b>RESULTS</b>After 2 weeks administration, VO-FA reduced the blood glucose in STZ-rats (P < 0. 01) dose-dependently, and up to 4 weeks the blood glucose was normalized (below 11.1 mmol.L(-1)) in some of STZ-rats, whereas did not decrease in normal rats. After administration of VO-FA at the dosage of 56.8 and 113.6 mg.kg(-1), the serum insulin levels were lowered in normal rats and STZ-rats, respectively. Moreover, VO-FA reduced glycohemoglobin, improved the glucose tolerance, and increased the liver glycogen and muscle glycogen contents in STZ-rats in a dose-dependent manner (P < 0. 05, P < 0. 01), but not in normal rats.</p><p><b>CONCLUSION</b>VO-FA could improve the glycometabolism in STZ-rats, but not in normal rats.</p>
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Base de dados:
WPRIM
Assunto principal:
Compostos Organometálicos
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Farmacologia
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Vanádio
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Sangue
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Glicemia
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Hemoglobinas Glicadas
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Distribuição Aleatória
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Ratos Sprague-Dawley
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Diabetes Mellitus Experimental
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Relação Dose-Resposta a Droga
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Article