Study on allergenicity of chlorogenic acid in Qingkailing injection / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1870-1873, 2011.
Article
em Zh
| WPRIM
| ID: wpr-354171
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the allergenicity of chlorogenic acid (CA) in Qingkailing injection.</p><p><b>METHOD</b>CA was administrated to Beagle dogs through intravenous injection, and on experimental allergic sensitization of guinea pigs, it was through intraperitoneal and intravenous injection. The behavioral changes of Beagle dogs and guinea pigs were observed, and changes of the content of histamine, IgE, IgG, IgM, ECP and IL-4 in blood were detected. Then the allergenicity of CA was determined by experimental anaphylactoid and allergic methods.</p><p><b>RESULT</b>There were no typical behavioral changes and increasement of the content of histamine, IgE, IgG, IgM, ECP and IL-4 in blood.</p><p><b>CONCLUSION</b>CA can not provoke anaphylactoid and allergic reactions.</p>
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Base de dados:
WPRIM
Assunto principal:
Comportamento Animal
/
Sangue
/
Medicamentos de Ervas Chinesas
/
Alérgenos
/
Química
/
Ácido Clorogênico
/
Hipersensibilidade a Drogas
/
Cobaias
/
Injeções
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Article