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Chemical constituents of Halenia elliptica / 中国中药杂志
Article em Zh | WPRIM | ID: wpr-356099
Biblioteca responsável: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents of Halenia elliptica.</p><p><b>METHOD</b>The air-dried whole plants of Halenia elliptica were extracted with 90% EtOH. The EtOH extract was condensed to a small amount of volume and extracted with petroleum ether, EtOAc and n-BuOH, successively. The compounds were isolated and purified by column chromatography from the EtOAc fraction, and identified based on spectral analyses (MS, 1H-NMR, 13C-NMR).</p><p><b>RESULT</b>12 compounds were isolated from H. elliptica, and characterized as 8-hydroxy-2-methylchromone (1), 5-methoxy-2-methylchromone (2), 7-epi-vogeloside (3), coniferl aldehyde (4), sinapaldehyde (5), norbellidifolin (6), 1-hydroxyl-2,3,4,6-tetramethoxyxanthone (7), 1-hydroxyl-2,3,4,7-tetramethoxyxanthone (8), 1-hydroxyl-2,3,5-trimethoxyxanthone (9), together with azelaic acid, beta-sitosterol, and oleanolic acid.</p><p><b>CONCLUSION</b>Compounds 1, 2 were new natural compounds and compounds 3-6, 10 were obtained from H. elliptica for the first time and compound 6 showed inhibitory activities against HBsAg and HBeAg secretion with IC50 value of 0.77 and < 0.62 mmol x L(-1), respectively.</p>
Assuntos
Texto completo: 1 Base de dados: WPRIM Assunto principal: Ácido Oleanólico / Sitosteroides / Espectrometria de Massas / Acroleína / Extratos Vegetais / Espectroscopia de Ressonância Magnética / Química / Cromatografia / Gentianaceae / Xantonas Idioma: Zh Revista: China Journal of Chinese Materia Medica Ano de publicação: 2011 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Ácido Oleanólico / Sitosteroides / Espectrometria de Massas / Acroleína / Extratos Vegetais / Espectroscopia de Ressonância Magnética / Química / Cromatografia / Gentianaceae / Xantonas Idioma: Zh Revista: China Journal of Chinese Materia Medica Ano de publicação: 2011 Tipo de documento: Article