The impact of diabetes mellitus and insulin interference on cortical SCF/KIT of mice / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 94-96, 2010.
Article
em Zh
| WPRIM
| ID: wpr-356207
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of cortical SCF/KIT system at different blood glucose level in mice.</p><p><b>METHODS</b>27 male C57 mice were randomly divided into control group, diabetes group, and diabetes plus insulin group. The diabetic mice were induced by streptozotocin. Western-blot and double-immunofluorescence histochemistry were used to detect the expression of SCF and KIT.</p><p><b>RESULTS</b>Both methods indicate that the level of S-SCF and M-SCF were decreased significantly in the diabetes group, and this trend can be reversed effectively when the insulin was utilized.</p><p><b>CONCLUSION</b>The decline of SCF might be one of underlying mechanisms of diabetic encephalopathy.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fisiologia
/
Regulação para Baixo
/
Córtex Cerebral
/
Fator de Células-Tronco
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Proteínas Proto-Oncogênicas c-kit
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Usos Terapêuticos
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Diabetes Mellitus Experimental
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Tratamento Farmacológico
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Insulina
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Metabolismo
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2010
Tipo de documento:
Article