Study on a selection of domestic standard for distributing delta3 - cefaclor to quantify and quality the cefaclor by high performance liquid chromatography

ABSTRACT

System suitability tests are an integral part of liquid chromatographic technique. They are used to verify the resolution (R) and reproducibility of the analysis to be done. HPLC method for assaying the related substances test of Cefaclor in raw material as well as in pharmaceutical dosage forms introduced to some pharmacopoeia such as EP, USP need to use Delta- 3 cefaclor as the internal standard to verify the suitability of chromatographic system. In case of lacking it to use, Cephalexin can be used as the internal standard in place of Delta-3 cefaclor. cell