Associations between the Expression of Mucins (MUC1, MUC2, MUC5AC, and MUC6) and Clinicopathologic Parameters of Human Breast Ductal Carcinomas / 한국유방암학회지
Journal of Breast Cancer
; : 152-158, 2013.
Article
em En
| WPRIM
| ID: wpr-38444
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
Mucins are members of the glycoprotein family expressed in benign and malignant epithelial cells. The aim of this study is to evaluate the relationships between the expression of mucins in breast ductal carcinoma and clinicopathologic parameters.METHODS:
We constructed tumor microarrays based on 240 cases of invasive ductal carcinoma and 40 cases of ductal carcinoma in situ (DCIS) using formalin fixed, paraffin embedded tissues. We examined the expressions of MUC1, MUC2, MUC5AC, and MUC6 by immunohistochemistry.RESULTS:
MUC1 demonstrated cytoplasmic, membranous, apical, and combinative expressions. Other mucins demonstrated cytoplasmic expression. In invasive ductal carcinoma, MUC1, MUC2, MUC5AC, and MUC6 were expressed in 93.6%, 6.2%, 4.8%, and 12.4% of cases, respectively; these rates were slightly, but not significantly, higher than observed in cases of DCIS. MUC1 expression was associated with estrogen receptor (ER) expression and negative MUC1 expression was associated with triple negativity. MUC6 expression was correlated with higher histologic grade, lymphatic invasion, lymph node metastasis, and HER2 positivity. No associations with any other clinicopathologic parameters were observed.CONCLUSION:
Most invasive ductal carcinomas of the breast express MUC1, and this expression is associated with ER expression. MUC6 expression is correlated with some clinicopathologic parameters that are indicators of poor prognosis. To evaluate the role of MUC6 as a potential biomarker, further studies are warranted.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Parafina
/
Prognóstico
/
Mama
/
Neoplasias da Mama
/
Glicoproteínas
/
Carcinoma Intraductal não Infiltrante
/
Citoplasma
/
Carcinoma Ductal
/
Células Epiteliais
/
Estrogênios
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Journal of Breast Cancer
Ano de publicação:
2013
Tipo de documento:
Article
País de publicação:
COREA DEL SUR
/
COREIA DO SUL
/
KR
/
SOUTH KOREA