Surgery for hepatocellular carcinoma in patients with liver cirrhosis associated with haemochromatosis / 中华肝胆外科杂志

ABSTRACT

Objective A retrospective analysis was carried out in 3 cases of hepatocellular carcinoma (HCC) and liver cirrhosis associated with haemochromatosis in our hospital, to investigate the effect of surgery, radio frequency ablation (RFA) and erythroapheresis in such patients. Methods 8 operations including partial liver resection and ultrasound-guided percutaneous transhepatic RFA were performed in 3 male patients with HCC and liver cirrhosis arising from haemochromatosis.Capecitabine was used in 2 patients. Erythroapheresis was performed in all 3 patients. Result Pathological examination showed hepatocellular carcinoma and liver cirrhosis. Positive Prussian blue staining confirmed the diagnosis of haemochromatosis. The mean survival time of 3 patients was 86 months (from 39 to 154 months). Conclusion It is important to discover HCC in patients with haemochromatosis as early as possible. The curative therapy is liver transplantation and hepatic resection. For patients with recurrent HCC, the combined therapy including RFA, chemotherapy and erythroapheresis could prolong their survival.