The roles of hypoxia-inducible factor-1 in ischemic brain injury / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
; (12): 300-305, 2010.
Article
em Zh
| WPRIM
| ID: wpr-389821
Biblioteca responsável:
WPRO
ABSTRACT
Hypoxia-inducible factor-1 (HIF-1), as a nuclear transcription regulator of the hypoxic response, is up-regulated during hypoxia, and it regulates a series of downstream target gene expression, such as vascular endothelial growth factor, glucose transporter and erythropoietin through binding with hypoxia response element. It plays important roles in angiogenesis, anerobic metabolism, cell survival, proliferation, migration, and differentiation.This article reviews the structure, function and activity regulation of HIF-1 and its roles in acute ischemic brain injury.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
International Journal of Cerebrovascular Diseases
Ano de publicação:
2010
Tipo de documento:
Article