Expression and ultrastructure location of PPAR-γ and COX-2 in endometrial carcinoma / 解剖学报
Acta Anatomica Sinica
; (6): 114-118, 2010.
Article
em Zh
| WPRIM
| ID: wpr-404337
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the development and prognosis of peroxisome proliferator-activated recepor-γ(PPAR-γ) and cyclooxygenase-2(COX-2) in endometrial carcinoma. Methods The electron microscopic immunohistochemical technique was used to observe the ultrastructure location of COX-2 protein labeled by colloidal gold in the endometrial carcinoma. Results 1.There were negative immunohistochemical staining signals of PPAR-γ in both the normal endometrium and hyperplasia endometrium, whereas, was positive staining in the endometrial carcinoma;2.The intensities of the COX-2 immunohistochemical staining were significantly statistical difference among the normal endometrium, the hyperplasia endometriu and the endometrial carcinoma(P<0.01);3. The COX-2 labelled by colloidal gold granules was observed in the endoplasmic reticulum, nuclear membrane and nuclei in the endometrial carcinoma. Conclusion Both PPAR-γ and the COX-2 might play an important role in the development of the endometrial carcinoma.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Acta Anatomica Sinica
Ano de publicação:
2010
Tipo de documento:
Article